In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …

Apoptosis, the first regulated form of cell death discovered in mammalian cells, is executed
by caspase-3/7, which are dormant in living cells but become activated by upstream …

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …