The diversified role of mitochondria in ferroptosis in cancer

Y Liu, S Lu, L Wu, L Yang, L Yang, J Wang - Cell death & disease, 2023 - nature.com
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …

Mitochondria-targeted BODIPY dyes for small molecule recognition, bio-imaging and photodynamic therapy

S Wang, L Gai, Y Chen, X Ji, H Lu, Z Guo - Chemical Society Reviews, 2024 - pubs.rsc.org
Mitochondria are essential for a diverse array of biological functions. There is increasing
research focus on develo** efficient tools for mitochondria-targeted detection and …

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

M Tan, Y Yin, X Ma, J Zhang, W Pan, M Tan… - Cell Death & …, 2023 - nature.com
The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …

[HTML][HTML] Oxidative stress–Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders

D Rotariu, EE Babes, DM Tit, M Moisi, C Bustea… - Biomedicine & …, 2022 - Elsevier
Oxidative stress is a complex biological process characterized by the excessive production
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …

Mitochondrial dysfunction and oxidative stress in heart disease

JN Peoples, A Saraf, N Ghazal, TT Pham… - … & molecular medicine, 2019 - nature.com
Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players
in molecular signaling and cell fate determination through reactive oxygen species (ROS) …

ROS generation and antioxidant defense systems in normal and malignant cells

AV Snezhkina, AV Kudryavtseva… - Oxidative medicine …, 2019 - Wiley Online Library
Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …

Structural features of small molecule antioxidants and strategic modifications to improve potential bioactivity

NC Charlton, M Mastyugin, B Török, M Török - Molecules, 2023 - mdpi.com
This review surveys the major structural features in various groups of small molecules that
are considered to be antioxidants, including natural and synthetic compounds alike. Recent …

Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health–a comprehensive review

M Alagawany, SS Elnesr, MR Farag, R Tiwari… - Veterinary …, 2021 - Taylor & Francis
Nutraceuticals have gained immense importance in poultry science recently considering the
nutritional and beneficial health effects of their constituents. Besides providing nutritional …

Mitochondrial glutathione in cellular redox homeostasis and disease manifestation

TH Chen, HC Wang, CJ Chang, SY Lee - International Journal of …, 2024 - mdpi.com
Mitochondria are critical for providing energy to maintain cell viability. Oxidative
phosphorylation involves the transfer of electrons from energy substrates to oxygen to …

Glutathione in brain disorders and aging

IY Iskusnykh, AA Zakharova, D Pathak - Molecules, 2022 - mdpi.com
Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …