Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies
LA Silva, TS Dermody - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Chikungunya virus (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal
inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and …
inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and …
Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen
Re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public
health concern. In the past 15 years, after decades of infrequent, sporadic outbreaks, the …
health concern. In the past 15 years, after decades of infrequent, sporadic outbreaks, the …
A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus
Chikungunya virus (CHIKV) infection causes acute disease characterized by fever, rash and
arthralgia, which progresses to severe and chronic arthritis in up to 50% of patients …
arthralgia, which progresses to severe and chronic arthritis in up to 50% of patients …
Mxra8 is a receptor for multiple arthritogenic alphaviruses
Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted
to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal …
to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal …
Passive immunotherapy of viral infections:'super-antibodies' enter the fray
LM Walker, DR Burton - Nature Reviews Immunology, 2018 - nature.com
Antibodies have been used for more than 100 years in the therapy of infectious diseases,
but a new generation of highly potent and/or broadly cross-reactive human monoclonal …
but a new generation of highly potent and/or broadly cross-reactive human monoclonal …
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
Infection with chikungunya virus (CHIKV) causes an acute illness characterized by fever,
rash, and arthralgia. However, CHIKV infection can sometimes progress to chronic arthritis …
rash, and arthralgia. However, CHIKV infection can sometimes progress to chronic arthritis …
A molecular understanding of alphavirus entry and antibody protection
Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human
infection and disease on a global scale. These viruses are classified as either arthritogenic …
infection and disease on a global scale. These viruses are classified as either arthritogenic …
Vaccine and therapeutic options to control chikungunya virus
AM Powers - Clinical microbiology reviews, 2018 - Am Soc Microbiol
Beginning in 2004, chikungunya virus (CHIKV) went from an endemic pathogen limited to
Africa and Asia that caused periodic outbreaks to a global pathogen. Given that outbreaks …
Africa and Asia that caused periodic outbreaks to a global pathogen. Given that outbreaks …
[HTML][HTML] Cryo-EM structure of chikungunya virus in complex with the Mxra8 receptor
Mxra8 is a receptor for multiple arthritogenic alphaviruses that cause debilitating acute and
chronic musculoskeletal disease in humans. Herein, we present a 2.2 Å resolution X-ray …
chronic musculoskeletal disease in humans. Herein, we present a 2.2 Å resolution X-ray …
LDLRAD3 is a receptor for Venezuelan equine encephalitis virus
Venezuelan equine encephalitis virus (VEEV) is a neurotropic alphavirus transmitted by
mosquitoes that causes encephalitis and death in humans. VEEV is a biodefence concern …
mosquitoes that causes encephalitis and death in humans. VEEV is a biodefence concern …