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[HTML][HTML] Therapeutic glycoprotein production in mammalian cells
Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …
production towards mammalian cell expression systems. The presence of glycosylation …
Advances in mammalian cell line development technologies for recombinant protein production
From 2006 to 2011, an average of 15 novel recombinant protein therapeutics have been
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …
[HTML][HTML] eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci
Transcription factors and DNA regulatory binding motifs are fundamental components of the
gene regulatory network. Here, by using genome-wide binding profiling, we show extensive …
gene regulatory network. Here, by using genome-wide binding profiling, we show extensive …
Near-atomic resolution visualization of human transcription promoter opening
In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that
assembles at the core promoter is required for the opening of the duplex DNA and …
assembles at the core promoter is required for the opening of the duplex DNA and …
The general transcription machinery and general cofactors
MC Thomas, CM Chiang - Critical reviews in biochemistry and …, 2006 - Taylor & Francis
In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
In vivo dynamics of RNA polymerase II transcription
We imaged transcription in living cells using a locus-specific reporter system, which allowed
precise, single-cell kinetic measurements of promoter binding, initiation and elongation …
precise, single-cell kinetic measurements of promoter binding, initiation and elongation …
Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation
In a little more than 10 years, nuclear receptor (NR) coregulators (coactivators and
corepressors) have contributed to our present realization that a great level of sophistication …
corepressors) have contributed to our present realization that a great level of sophistication …
Dysregulation of the basal RNA polymerase transcription apparatus in cancer
Mutations that directly affect transcription by RNA polymerases rank among the most central
mediators of malignant transformation, but the frequency of new anticancer drugs that …
mediators of malignant transformation, but the frequency of new anticancer drugs that …
Three-step mechanism of promoter escape by RNA polymerase II
The transition from transcription initiation to elongation is highly regulated in human cells but
remains incompletely understood at the structural level. In particular, it is unclear how …
remains incompletely understood at the structural level. In particular, it is unclear how …
Nuclear receptor coregulators and human disease
Nuclear receptor (NR) coregulators (coactivators and corepressors) are essential elements
in regulating nuclear receptor-mediated transcription. In a little more than a decade since …
in regulating nuclear receptor-mediated transcription. In a little more than a decade since …