Distinct coordination chemistry of Fe (III)-based MRI probes

EA Kras, EM Snyder, GE Sokolow… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Contrast agents are used in approximately 40% of all magnetic resonance
imaging (MRI) procedures to improve the quality of the images based on the distribution and …

Applications for transition-metal chemistry in contrast-enhanced magnetic resonance imaging

A Gupta, P Caravan, WS Price… - Inorganic …, 2020 - ACS Publications
Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …

A Class of FeIII Macrocyclic Complexes with Alcohol Donor Groups as Effective T1 MRI Contrast Agents

EM Snyder, D Asik, SM Abozeid, A Burgio… - Angewandte …, 2020 - Wiley Online Library
Early studies suggested that FeIII complexes cannot compete with GdIII complexes as T1
MRI contrast agents. Now it is shown that one member of a class of high‐spin macrocyclic …

Bioimaging agents based on redox-active transition metal complexes

SS Xue, Y Pan, W Pan, S Liu, N Li, B Tang - Chemical Science, 2022 - pubs.rsc.org
Detecting the fluctuation and distribution of various bioactive species in biological systems is
of great importance in determining diseases at their early stages. Metal complex-based …

Redox-Responsive MRI Probes Based on First-Row Transition-Metal Complexes

JR Morrow, JJ Raymond, MSI Chowdhury… - Inorganic …, 2022 - ACS Publications
The presence of multiple oxidation and spin states of first-row transition-metal complexes
facilitates the development of switchable MRI probes. Redox-responsive probes capitalize …

Liposomal MRI probes containing encapsulated or amphiphilic Fe (iii) coordination complexes

MSI Chowdhury, EA Kras, SG Turowski… - Biomaterials …, 2023 - pubs.rsc.org
Liposomes containing high-spin Fe (III) coordination complexes were prepared towards the
production of T1 MRI probes with improved relaxivity. The amphiphilic Fe (III) complexes …

The first-row transition metals in the periodic table of medicine

C Van Cleave, DC Crans - Inorganics, 2019 - mdpi.com
In this manuscript, we describe medical applications of each first-row transition metal
including nutritional, pharmaceutical, and diagnostic applications. The 10 first-row transition …

Co (ii) complexes of tetraazamacrocycles appended with amide or hydroxypropyl groups as paraCEST agents

JJ Raymond, SM Abozeid, GE Sokolow, CJ Bond… - Dalton …, 2023 - pubs.rsc.org
Co (II) complexes of 1, 4, 7, 10-tetraazacyclododecane (CYCLEN) or 1, 4, 8, 11-
tetraazacyclotetradecane (CYCLAM) with 2-hydroxypropyl or carbamoylmethyl (amide) …

Synthesis, Characterization, Modeling, and Antimicrobial Activity of FeIII, CoII, NiII, CuII, and ZnII Complexes Based on Tri‐substituted Imidazole Ligand

M Ismael, A Abdou… - … für anorganische und …, 2018 - Wiley Online Library
The reaction of the synthesized 2‐(4, 5‐diphenyl‐1H‐imidazol‐2‐yl) phenol,(HL) ligand with
FeIII, CoII, NiII, CuII, and ZnII ions at room temperature resulted in the formation of the five …

Comparison of phosphonate, hydroxypropyl and carboxylate pendants in Fe (III) macrocyclic complexes as MRI contrast agents

EA Kras, SM Abozeid, W Eduardo, JA Spernyak… - Journal of inorganic …, 2021 - Elsevier
Fe (III) macrocyclic complexes containing a macrocycle and three pendant groups including
phosphonate (NOTP= 1, 4, 7-triazacyclononane-1, 4, 7-triyl-tris (methylenephosphonic acid) …