A practical guide to environmental association analysis in landscape genomics

C Rellstab, F Gugerli, AJ Eckert, AM Hancock… - Molecular …, 2015 - Wiley Online Library
Landscape genomics is an emerging research field that aims to identify the environmental
factors that shape adaptive genetic variation and the gene variants that drive local …

Sequencing pools of individuals—mining genome-wide polymorphism data without big funding

C Schlötterer, R Tobler, R Kofler, V Nolte - Nature Reviews Genetics, 2014 - nature.com
The analysis of polymorphism data is becoming increasingly important as a complementary
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …

LEA: An R package for landscape and ecological association studies

E Frichot, O François - Methods in Ecology and Evolution, 2015 - Wiley Online Library
Based on population genomic and environmental data, genomewide ecological association
studies aim at detecting allele frequencies that exhibit significant statistical association with …

Genome-wide scan for adaptive divergence and association with population-specific covariates

M Gautier - Genetics, 2015 - academic.oup.com
In population genomics studies, accounting for the neutral covariance structure across
population allele frequencies is critical to improve the robustness of genome-wide scan …

Detecting natural selection in genomic data

JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

Robust identification of local adaptation from allele frequencies

T Günther, G Coop - Genetics, 2013 - academic.oup.com
Comparing allele frequencies among populations that differ in environment has long been a
tool for detecting loci involved in local adaptation. However, such analyses are complicated …

Testing for associations between loci and environmental gradients using latent factor mixed models

E Frichot, SD Schoville, G Bouchard… - Molecular biology and …, 2013 - academic.oup.com
Adaptation to local environments often occurs through natural selection acting on a large
number of loci, each having a weak phenotypic effect. One way to detect these loci is to …

How culture shaped the human genome: bringing genetics and the human sciences together

KN Laland, J Odling-Smee, S Myles - Nature Reviews Genetics, 2010 - nature.com
Researchers from diverse backgrounds are converging on the view that human evolution
has been shaped by gene–culture interactions. Theoretical biologists have used population …

The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation

JK Pritchard, JK Pickrell, G Coop - Current biology, 2010 - cell.com
There has long been interest in understanding the genetic basis of human adaptation. To
what extent are phenotypic differences among human populations driven by natural …

Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution

M Fumagalli, M Sironi, U Pozzoli… - PLoS …, 2011 - journals.plos.org
Previous genome-wide scans of positive natural selection in humans have identified a
number of non-neutrally evolving genes that play important roles in skin pigmentation …