Comprehensive review of targeted therapy for colorectal cancer

YH **e, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Designing deep learning studies in cancer diagnostics

A Kleppe, OJ Skrede, S De Raedt, K Liestøl… - Nature Reviews …, 2021 - nature.com
The number of publications on deep learning for cancer diagnostics is rapidly increasing,
and systems are frequently claimed to perform comparable with or better than clinicians …

Vessel co-option in cancer

EA Kuczynski, PB Vermeulen, F Pezzella… - Nature reviews Clinical …, 2019 - nature.com
All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study

OJ Skrede, S De Raedt, A Kleppe, TS Hveem, K Liestøl… - The Lancet, 2020 - thelancet.com
Background Improved markers of prognosis are needed to stratify patients with early-stage
colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to …

The American Society of Colon and Rectal Surgeons clinical practice guidelines for the treatment of colon cancer

JD Vogel, C Eskicioglu, MR Weiser… - Diseases of the Colon …, 2017 - journals.lww.com
Abstract The American Society of Colon and Rectal Surgeons is dedicated to ensuring high-
quality patient care by advancing the science, prevention, and management of disorders …

Personalizing adjuvant therapy for patients with colorectal cancer

L Yang, J Yang, A Kleppe, HE Danielsen… - Nature Reviews Clinical …, 2024 - nature.com
The current standard-of-care adjuvant treatment for patients with colorectal cancer (CRC)
comprises a fluoropyrimidine (5-fluorouracil or capecitabine) as a single agent or in …

A clinical decision support system optimising adjuvant chemotherapy for colorectal cancers by integrating deep learning and pathological staging markers: a …

A Kleppe, OJ Skrede, S De Raedt, TS Hveem… - The lancet …, 2022 - thelancet.com
Summary Background The DoMore-v1-CRC marker was recently developed using deep
learning and conventional haematoxylin and eosin-stained tissue sections, and was …

Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study

E Domingo, L Freeman-Mills, E Rayner… - The lancet …, 2016 - thelancet.com
Background Precision cancer medicine depends on defining distinct tumour subgroups
using biomarkers that may occur at very modest frequencies. One such subgroup comprises …

S3-leitlinie–kolorektales karzinom

W Schmiegel, B Buchberger… - Zeitschrift für …, 2017 - thieme-connect.com
2.1 Geltungsbereich und Zweck 2.1. 1. Zielsetzung und Fragestellung Das Kolorektale
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …

Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions

S Chakrabarti, CY Peterson, D Sriram… - World journal of …, 2020 - pmc.ncbi.nlm.nih.gov
Colon cancer continues to be one of the leading causes of mortality and morbidity
throughout the world despite the availability of reliable screening tools and effective …