Two histone marks, H3K27me3 and H3K9me3, are well known for their repressive roles in
the genic and nongenic regions of metazoan genomes. Several protein complexes are …

About half of the mammalian genome is occupied by DNA sequences that originate from
transposable elements. Retrotransposons can modulate gene expression in different ways …

ZFP42 zinc finger protein (REX1), a pluripotency marker in mouse pluripotent stem cells, has
been identified as a tumor suppressor in several human cancers. However, the function of …

Polycomb repressive complexes (PRCs) are important chromatin regulators of embryonic
stem (ES) cell function. RYBP binds Polycomb H2A monoubiquitin ligases Ring1A and …

Abstract Polycomb Group (PcG) proteins are crucial for epigenetic inheritance of cell identity
and are functionally conserved from Drosophila to humans. PcG proteins regulate …

Abstract Rex1/Zfp42 is a Yy1-related zinc-finger protein whose expression is frequently used
to identify pluripotent stem cells. We show that depletion of Rex1 levels notably affected self …

Dystonia is a neurologic disorder associated with an increasingly large number of genetic
variants in many genes, resulting in characteristic disturbances in volitional movement …

Over the last decades significant advances have been made in our understanding of the
molecular mechanisms controlling organismal development. Among these mechanisms the …

Rex1/Zfp42 is a nuclear protein that is highly conserved in mammals, and widely used as an
embryonic stem (ES) cell marker. Although Rex1 expression is associated with enhanced …

Background Yin Yang 2 (YY2) is a zinc finger protein closely related to the well-
characterized Yin Yang 1 (YY1). YY1 is a DNA-binding transcription factor, with defined …