Decellularization for the retention of tissue niches
Decellularization of natural tissues to produce extracellular matrix is a promising method for
three-dimensional scaffolding and for understanding microenvironment of the tissue of …
three-dimensional scaffolding and for understanding microenvironment of the tissue of …
How the extracellular matrix shapes neural development
KR Long, WB Huttner - Royal Society Open Biology, 2019 - royalsocietypublishing.org
During development, both cells and tissues must acquire the correct shape to allow their
proper function. This is especially relevant in the nervous system, where the shape of …
proper function. This is especially relevant in the nervous system, where the shape of …
The soft mechanical signature of glial scars in the central nervous system
Injury to the central nervous system (CNS) alters the molecular and cellular composition of
neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons …
neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons …
Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …
Recent progress in translational engineered in vitro models of the central nervous system
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …
models of the CNS. Current animal models lack many essential human characteristics (in …
Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array
The brain's extracellular matrix (ECM) is a macromolecular network composed of
glycosaminoglycans, proteoglycans, glycoproteins, and fibrous proteins. In vitro studies …
glycosaminoglycans, proteoglycans, glycoproteins, and fibrous proteins. In vitro studies …
Restoring function after spinal cord injury: towards clinical translation of experimental strategies
Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …
complications and maximising residual function by rehabilitation. Improved understanding of …
Electroconductive PEDOT nanoparticle integrated scaffolds for spinal cord tissue repair
Background Hostile environment around the lesion site following spinal cord injury (SCI)
prevents the re-establishment of neuronal tracks, thus significantly limiting the regenerative …
prevents the re-establishment of neuronal tracks, thus significantly limiting the regenerative …
Pathophysiology, classification and comorbidities after traumatic spinal cord injury
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …
communication between the brain and the rest of the body, conveying complex sensory and …
Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
The inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal
regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial …
regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial …