The advent of powerful acid-suppressive drugs, such as proton pump inhibitors (PPIs), has
revolutionized the management of acid-related diseases and has minimized the role of …

Introduction: The introduction of proton pump inhibitors (PPIs) into clinical practice has
greatly improved our therapeutic approach to acid-related diseases for their efficacy and …

The gastrointestinal (GI) mucosal barrier is continuously exposed to noxious toxins, reactive
oxygen species, microbes, and drugs, leading to the development of inflammatory, erosive …

The magnitude of the suspected increase in risk of acute interstitial nephritis among proton
pump inhibitor users is uncertain. Here, we conducted a nested case-control study using …

Background Recent research indicates that use of proton pump inhibitors (PPIs) is
associated with pneumonia, but existing evidence is inconclusive because of …

Background It is 40 years since the discovery of Helicobacter pylori infection. Over that time
major changes have occurred in esophagogastroduodenoscopy (EGD) findings. The aim of …

BACKGROUNDClostridium difficile is the principal infectious cause of antibiotic-associated
diarrhea and accounts for 12% of hospital-acquired infections. Recent literature has shown …

Purpose To analyse the prevalence of long‐term use of proton pump inhibitors (PPI) with
respect to underlying diseases and drugs, and to find predictors for such treatment when an …

Abstract Background Proton pump inhibitors (PPIs) can lead to several adverse effects
among the elderly, particularly when used inappropriately or in contrast to evidence …

What is known and objective Proton pump inhibitor (PPI) prescribing may often be
inappropriate and expose patients to a risk of adverse effects, while incurring unnecessary …