The rapid development of precision medicine in recent years has started to challenge
diagnostic pathology with respect to its ability to analyze histological images and …

To study complex biological processes holistically, it is imperative to take an integrative
approach that combines multi-omics data to highlight the interrelationships of the involved …

Recent advances in cancer characterization have consistently revealed marked
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …

Multi‐omics studies promise the improved characterization of biological processes across
molecular layers. However, methods for the unsupervised integration of the resulting …

Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and
extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM …

T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we
explored the microenvironmental signals regulating T cell exhaustion using a model of …

BCL-2 inhibition has been shown to be effective in acute myeloid leukemia (AML) in
combination with hypomethylating agents or low-dose cytarabine. However, resistance and …

In-depth modeling of the complex interplay among multiple omics data measured from
cancer cell lines or patient tumors is providing new opportunities toward identification of …

The treatment of AML with high-dose cytarabine and anthracycline-based intensive
chemotherapy has remained the standard of care for the last four decades. 1 Despite the …

Tumour heterogeneity encompasses both the malignant cells and their microenvironment.
While heterogeneity between individual patients is known to affect the efficacy of cancer …