[HTML][HTML] Novel SARS-CoV-2 variants: the pandemics within the pandemic

E Boehm, I Kronig, RA Neher, I Eckerle, P Vetter… - Clinical Microbiology …, 2021 - Elsevier
Background Many new variants of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) have been termed variants of concern/interest (VOC/I) because of the greater …

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

C Sun, C **e, GL Bu, LY Zhong, MS Zeng - Signal Transduction and …, 2022 - nature.com
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

A Escalera, AS Gonzalez-Reiche, S Aslam, I Mena… - Cell host & …, 2022 - cell.com
SARS-CoV-2 lineages have diverged into highly prevalent variants termed" variants of
concern"(VOCs). Here, we characterized emerging SARS-CoV-2 spike polymorphisms in …

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2

AM Szemiel, A Merits, RJ Orton, OA MacLean… - PLoS …, 2021 - journals.plos.org
Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small
molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports …

The spike of concern—the novel variants of SARS-CoV-2

A Winger, T Caspari - Viruses, 2021 - mdpi.com
The high sequence identity of the first SARS-CoV-2 samples collected in December 2019 at
Wuhan did not foretell the emergence of novel variants in the United Kingdom, North and …

[HTML][HTML] Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination

S Cobey, DB Larremore, YH Grad… - Nature Reviews …, 2021 - nature.com
When vaccines are in limited supply, expanding the number of people who receive some
vaccine, such as by halving doses or increasing the interval between doses, can reduce …

SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection

L Bashor, RB Gagne, AM Bosco-Lauth… - Proceedings of the …, 2021 - National Acad Sciences
SARS-CoV-2 spillback from humans into domestic and wild animals has been well
documented, and an accumulating number of studies illustrate that human-to-animal …

From Deer-to-Deer: SARS-CoV-2 is efficiently transmitted and presents broad tissue tropism and replication sites in white-tailed deer

M Martins, PM Boggiatto, A Buckley… - PLoS …, 2022 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19) in humans, has a broad host range, and is able to …

Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts

AL Valesano, KE Rumfelt, DE Dimcheff, CN Blair… - PLoS …, 2021 - journals.plos.org
Analysis of SARS-CoV-2 genetic diversity within infected hosts can provide insight into the
generation and spread of new viral variants and may enable high resolution inference of …

Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks

KM Braun, GK Moreno, C Wagner, MA Accola… - PLoS …, 2021 - journals.plos.org
The emergence of divergent SARS-CoV-2 lineages has raised concern that novel variants
eliciting immune escape or the ability to displace circulating lineages could emerge within …