The algal past and parasite present of the apicoplast
Plasmodium and Toxoplasma are genera of apicomplexan parasites that infect millions of
people each year. The former causes malaria, and the latter causes neurotropic infections …
people each year. The former causes malaria, and the latter causes neurotropic infections …
Organelle dynamics in apicomplexan parasites
Apicomplexan parasites, such as Toxoplasma gondii and Plasmodium falciparum, are the
cause of many important human and animal diseases. While T. gondii tachyzoites replicate …
cause of many important human and animal diseases. While T. gondii tachyzoites replicate …
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass …
Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria
Z Chahine, S Abel, T Hollin, GL Barnes, JH Chung… - Science, 2024 - science.org
We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene
natural products that is effective against drug-sensitive and drug-resistant Plasmodium …
natural products that is effective against drug-sensitive and drug-resistant Plasmodium …
Metabolic quirks and the colourful history of the Euglena gracilis secondary plastid
Euglena spp. are phototrophic flagellates with considerable ecological presence and
impact. Euglena gracilis harbours secondary green plastids, but an incompletely …
impact. Euglena gracilis harbours secondary green plastids, but an incompletely …
Compartmentation of redox metabolism in malaria parasites
S Kehr, N Sturm, S Rahlfs, JM Przyborski… - PLoS …, 2010 - journals.plos.org
Malaria, caused by the apicomplexan parasite Plasmodium, still represents a major threat to
human health and welfare and leads to about one million human deaths annually …
human health and welfare and leads to about one million human deaths annually …
[HTML][HTML] Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts
The malaria parasite Plasmodium possesses a relict, non-photosynthetic plastid known as
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …
Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins
Most apicomplexan parasites harbor a relict chloroplast, the apicoplast, that is critical for
their survival. Whereas the apicoplast maintains a small genome, the bulk of its proteins are …
their survival. Whereas the apicoplast maintains a small genome, the bulk of its proteins are …
Regulation of Atg8 membrane deconjugation by cysteine proteases in the malaria parasite Plasmodium berghei
A Mishra, A Varshney, S Mishra - Cellular and Molecular Life Sciences, 2023 - Springer
During macroautophagy, the Atg8 protein is conjugated to phosphatidylethanolamine (PE)
in autophagic membranes. In Apicomplexan parasites, two cysteine proteases, Atg4 and …
in autophagic membranes. In Apicomplexan parasites, two cysteine proteases, Atg4 and …
An Unusual ERAD-Like Complex Is Targeted to the Apicoplast of Plasmodium falciparum
S Spork, JA Hiss, K Mandel, M Sommer… - Eukaryotic …, 2009 - Am Soc Microbiol
Many apicomplexan parasites, including Plasmodium falciparum, harbor a so-called
apicoplast, a complex plastid of red algal origin which was gained by a secondary …
apicoplast, a complex plastid of red algal origin which was gained by a secondary …