Ribosome biogenesis factors—from names to functions
K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
Ribosome biogenesis in cancer: new players and therapeutic avenues
The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …
The complete sequence of a human genome
Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …
The discovery of ribosome heterogeneity and its implications for gene regulation and organismal life
NR Genuth, M Barna - Molecular cell, 2018 - cell.com
The ribosome has recently transitioned from being viewed as a passive, indiscriminate
machine to a more dynamic macromolecular complex with specialized roles in the cell …
machine to a more dynamic macromolecular complex with specialized roles in the cell …
New insights into the generation and role of de novo mutations in health and disease
Aside from inheriting half of the genome of each of our parents, we are born with a small
number of novel mutations that occurred during gametogenesis and postzygotically. Recent …
number of novel mutations that occurred during gametogenesis and postzygotically. Recent …
The functional role of long non-coding RNA in human carcinomas
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
Nucleolar stress: From development to cancer
MC Lafita-Navarro, M Conacci-Sorrell - Seminars in cell & developmental …, 2023 - Elsevier
The nucleolus is a large nuclear membraneless organelle responsible for ribosome
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …
Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression
The ribosome, the integration point for protein synthesis in the cell, is conventionally
considered a homogeneous molecular assembly that only passively contributes to gene …
considered a homogeneous molecular assembly that only passively contributes to gene …
[HTML][HTML] Nucleolar organizer regions: genomic 'dark matter'requiring illumination
B McStay - Genes & development, 2016 - genesdev.cshlp.org
Nucleoli form around tandem arrays of a ribosomal gene repeat, termed nucleolar organizer
regions (NORs). During metaphase, active NORs adopt a characteristic undercondensed …
regions (NORs). During metaphase, active NORs adopt a characteristic undercondensed …