Telomeres in cancer: tumour suppression and genome instability
J Maciejowski, T de Lange - Nature reviews Molecular cell biology, 2017 - nature.com
The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …
Advances in the diagnosis and treatment of pediatric acute lymphoblastic leukemia
H Inaba, CH Pui - Journal of clinical medicine, 2021 - mdpi.com
The outcomes of pediatric acute lymphoblastic leukemia (ALL) have improved remarkably
during the last five decades. Such improvements were made possible by the incorporation of …
during the last five decades. Such improvements were made possible by the incorporation of …
Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …
However, the currently most practicable approaches rely on the generation of DNA double …
The genomic landscape of pediatric acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …
Chromothripsis drives the evolution of gene amplification in cancer
Focal chromosomal amplification contributes to the initiation of cancer by mediating
overexpression of oncogenes,–, and to the development of cancer therapy resistance by …
overexpression of oncogenes,–, and to the development of cancer therapy resistance by …
[HTML][HTML] Patterns of somatic structural variation in human cancer genomes
A key mutational process in cancer is structural variation, in which rearrangements delete,
amplify or reorder genomic segments that range in size from kilobases to whole …
amplify or reorder genomic segments that range in size from kilobases to whole …
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic
rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer …
rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer …
Mechanisms generating cancer genome complexity from a single cell division error
INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …
mutational process, common during tumorigenesis, that results in gene amplification and …
Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting
The CRISPR/Cas9 system enables genome editing and somatic cell genetic screens in
mammalian cells. We performed genome-scale loss-of-function screens in 33 cancer cell …
mammalian cells. We performed genome-scale loss-of-function screens in 33 cancer cell …
Chromothripsis and kataegis induced by telomere crisis
Telomere crisis occurs during tumorigenesis when depletion of the telomere reserve leads
to frequent telomere fusions. The resulting dicentric chromosomes have been proposed to …
to frequent telomere fusions. The resulting dicentric chromosomes have been proposed to …