[HTML][HTML] Guidelines for clinical translation and commercialization of extracellular vesicles and exosomes based therapeutics

K Cheng, R Kalluri - Extracellular Vesicle, 2023 - Elsevier
Extracellular vesicles (EVs) are lipid-bilayer delimited membrane structures released by
cells, and play a role in intercell communication and disease development. The Global …

Ongoing clinical trials of nonviral siRNA therapeutics

EA Narasipura, R VanKeulen-Miller, Y Ma… - Bioconjugate …, 2023 - ACS Publications
Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

Current status and outlook of advances in exosome isolation

W Liu, Z Ma, X Kang - Analytical and Bioanalytical Chemistry, 2022 - Springer
Exosomes are extracellular vesicles with a diameter ranging from 30 to 150 nm, which are
an important medium for intercellular communication and are closely related to the …

Biogenesis, composition and potential therapeutic applications of mesenchymal stem cells derived exosomes in various diseases

YG Yuan, JL Wang, YX Zhang, L Li… - International Journal …, 2023 - Taylor & Francis
Exosomes are nanovesicles with a wide range of chemical compositions used in many
different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are …

Extracellular vesicle preparation and analysis: a state‐of‐the‐art review

Z Wang, X Zhou, Q Kong, H He, J Sun, W Qiu… - Advanced …, 2024 - Wiley Online Library
In recent decades, research on Extracellular Vesicles (EVs) has gained prominence in the
life sciences due to their critical roles in both health and disease states, offering promising …

Bioreducible exosomes encapsulating glycolysis inhibitors potentiate mitochondria-targeted sonodynamic cancer therapy via cancer-targeted drug release and …

TGN Cao, QT Hoang, JH Kang, SJ Kang… - Biomaterials, 2023 - Elsevier
Nanocarrier-assisted sonodynamic therapy (SDT) has shown great potential for the effective
and targeted treatment of deep-seated tumors by overcoming the critical limitations of …

[HTML][HTML] Extracellular vesicle-embedded materials

Y Ma, S Brocchini, GR Williams - Journal of Controlled Release, 2023 - Elsevier
Extracellular vesicles (EVs) are small membrane-bound vesicles released by cells. EVs are
emerging as a promising class of therapeutic entity that could be adapted in formulation due …

Exosomes: a promising avenue for cancer diagnosis beyond treatment

Z Wang, Q Wang, F Qin, J Chen - Frontiers in Cell and …, 2024 - frontiersin.org
Exosomes, extracellular vesicles secreted by cells, have garnered significant attention in
recent years for their remarkable therapeutic potential. These nanoscale carriers can be …

Global trends of exosomes application in clinical trials: a sco** review

M Rahnama, M Heidari, Z Poursalehi… - Stem Cell Reviews and …, 2024 - Springer
Background Exosomes, nano-sized extracellular vesicles, have emerged as a promising
tool for the diagnosis and treatment of various intractable diseases, including chronic …

Broccoli-derived exosome-like nanoparticles alleviate loperamide-induced constipation, in correlation with regulation on gut microbiota and tryptophan metabolism

T Duan, X Wang, X Dong, C Wang… - Journal of Agricultural …, 2023 - ACS Publications
Constipation, a common gastrointestinal dysfunction, damages patients' life quality and
predisposes them to other serious diseases. Current strategies against constipation often …