Host microbiome-pathogen interactions in pediatric infections

JH Hurst, SM Heston, MS Kelly - Current Opinion in Infectious …, 2023 - journals.lww.com
The microbiome has emerged as a key modifier of infection susceptibility and severity
among children. Further research is needed to define the roles of microbes other than …

Unique microbial landscape in the human oropharynx during different types of acute respiratory tract infections

H Li, X Wu, H Zeng, B Chang, Y Cui, J Zhang, R Wang… - Microbiome, 2023 - Springer
Background Secondary bacterial infections and pneumonia are major mortality causes of
respiratory viruses, and the disruption of the upper respiratory tract (URT) microbiota is a …

Microbiome modifications by steroids during viral exacerbation of asthma and in healthy mice

K Yagi, AD Ethridge, NR Falkowski… - … of Physiology-Lung …, 2024 - journals.physiology.org
In the present studies, the assessment of how viral exacerbation of asthmatic responses with
and without pulmonary steroid treatment alters the microbiome in conjunction with immune …

Proteomics endoty** of infants with severe bronchiolitis and risk of childhood asthma

T Ooka, Y Raita, M Fujiogi, RJ Freishtat, RE Gerszten… - Allergy, 2022 - Wiley Online Library
Background Bronchiolitis is the leading cause of hospitalization in US infants and a major
risk factor for childhood asthma. Growing evidence supports clinical heterogeneity within …

The develo** immune system in preterm born infants: From contributor to potential solution for respiratory tract infections and wheezing

IC van Duuren, ORJ van Hengel, J Penders, L Duijts… - Allergy, 2024 - Wiley Online Library
Moderate‐late preterm‐born infants experience more frequent and severe respiratory tract
infections and wheezing compared to term‐born infants. Decreasing the risk on respiratory …

Can therapeutic targeting of the human microbiome influence asthma management? A pro/con debate

AL Kau, AL Rosen, C Rosas-Salazar - The Journal of Allergy and Clinical …, 2024 - Elsevier
Asthma is a clinically heterogeneous disease, and despite substantial improvements in
therapies, there remains an unmet need for well-tolerated, effective treatments …

Viral genetic determinants of prolonged respiratory syncytial virus infection among infants in a healthy term birth cohort

D Lawless, CG McKennan, SR Das… - The Journal of …, 2023 - academic.oup.com
Background Respiratory syncytial virus (RSV) is associated with acute respiratory infection.
We sought to identify RSV variants associated with prolonged infection. Methods Among …

Exclusive breast-feeding, the early-life microbiome and immune response, and common childhood respiratory illnesses

C Rosas-Salazar, MH Shilts, ZZ Tang, Q Hong… - Journal of Allergy and …, 2022 - Elsevier
Background The impact of breast-feeding on certain childhood respiratory illnesses remains
controversial. Objective We sought to examine the effect of exclusive breast-feeding on the …

Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and disease

N Quinn-Bohmann, JA Freixas-Coutin, J Seo… - BMC biology, 2024 - Springer
Background The human upper respiratory tract (URT) microbiome, like the gut microbiome,
varies across individuals and between health and disease states. However, study-to-study …

Upper respiratory tract microbiota dynamics following COVID-19 in adults

C Rosas-Salazar, KS Kimura, MH Shilts… - Microbial …, 2023 - microbiologyresearch.org
To date, little is known about the effect of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) …