The Role of the Microbiome in Pediatric Respiratory Diseases

ET Zemanick, C Rosas-Salazar - Clinics in Chest …, 2024 - chestmed.theclinics.com
The communities of bacteria and other microorganisms living in and on the human body—
which constitute the microbiome—have been studied for more than a century, but research …

Unique microbial landscape in the human oropharynx during different types of acute respiratory tract infections

H Li, X Wu, H Zeng, B Chang, Y Cui, J Zhang, R Wang… - Microbiome, 2023 - Springer
Background Secondary bacterial infections and pneumonia are major mortality causes of
respiratory viruses, and the disruption of the upper respiratory tract (URT) microbiota is a …

Microbiome modifications by steroids during viral exacerbation of asthma and in healthy mice

K Yagi, AD Ethridge, NR Falkowski… - … of Physiology-Lung …, 2024 - journals.physiology.org
In the present studies, the assessment of how viral exacerbation of asthmatic responses with
and without pulmonary steroid treatment alters the microbiome in conjunction with immune …

The develo** immune system in preterm born infants: From contributor to potential solution for respiratory tract infections and wheezing

IC van Duuren, ORJ van Hengel, J Penders, L Duijts… - Allergy, 2024 - Wiley Online Library
Moderate‐late preterm‐born infants experience more frequent and severe respiratory tract
infections and wheezing compared to term‐born infants. Decreasing the risk on respiratory …

Proteomics endoty** of infants with severe bronchiolitis and risk of childhood asthma

T Ooka, Y Raita, M Fujiogi, RJ Freishtat, RE Gerszten… - Allergy, 2022 - Wiley Online Library
Background Bronchiolitis is the leading cause of hospitalization in US infants and a major
risk factor for childhood asthma. Growing evidence supports clinical heterogeneity within …

Exclusive breast-feeding, the early-life microbiome and immune response, and common childhood respiratory illnesses

C Rosas-Salazar, MH Shilts, ZZ Tang, Q Hong… - Journal of Allergy and …, 2022 - Elsevier
Background The impact of breast-feeding on certain childhood respiratory illnesses remains
controversial. Objective We sought to examine the effect of exclusive breast-feeding on the …

Can therapeutic targeting of the human microbiome influence asthma management? A pro/con debate

AL Kau, AL Rosen, C Rosas-Salazar - The Journal of Allergy and Clinical …, 2024 - Elsevier
Asthma is a clinically heterogeneous disease, and despite substantial improvements in
therapies, there remains an unmet need for well-tolerated, effective treatments …

Viral genetic determinants of prolonged respiratory syncytial virus infection among infants in a healthy term birth cohort

D Lawless, CG McKennan, SR Das… - The Journal of …, 2023 - academic.oup.com
Background Respiratory syncytial virus (RSV) is associated with acute respiratory infection.
We sought to identify RSV variants associated with prolonged infection. Methods Among …

Upper respiratory tract microbiota dynamics following COVID-19 in adults

C Rosas-Salazar, KS Kimura, MH Shilts… - Microbial …, 2023 - microbiologyresearch.org
To date, little is known about the effect of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) …

New paradigms in acute viral bronchiolitis: Is it time to change our approach?

JA Castro-Rodriguez, P Astudillo, S Puranik… - Paediatric Respiratory …, 2024 - Elsevier
Viral bronchiolitis is the most common pediatric acute respiratory infection leading to
hospitalization, and it causes significant healthcare burden worldwide. Current guidelines …