Glycosyltransferases: structures, functions, and mechanisms

LL Lairson, B Henrissat, GJ Davies… - Annu. Rev …, 2008 - annualreviews.org
Glycosyltransferases catalyze glycosidic bond formation using sugar donors containing a
nucleoside phosphate or a lipid phosphate leaving group. Only two structural folds, GT-A …

Toward automated enzymatic synthesis of oligosaccharides

L Wen, G Edmunds, C Gibbons, J Zhang… - Chemical …, 2018 - ACS Publications
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

Structure, substrate recognition and initiation of hyaluronan synthase

FP Maloney, J Kuklewicz, RA Corey, Y Bi, R Ho… - Nature, 2022 - nature.com
Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine
and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular …

Crystallographic snapshot of cellulose synthesis and membrane translocation

JLW Morgan, J Strumillo, J Zimmer - Nature, 2013 - nature.com
Cellulose, the most abundant biological macromolecule, is an extracellular, linear polymer
of glucose molecules. It represents an essential component of plant cell walls but is also …

An evolving hierarchical family classification for glycosyltransferases

PM Coutinho, E Deleury, GJ Davies… - Journal of molecular …, 2003 - Elsevier
Glycosyltransferases are a ubiquitous group of enzymes that catalyse the transfer of a sugar
moiety from an activated sugar donor onto saccharide or non-saccharide acceptors …

Structures and mechanisms of glycosyltransferases

C Breton, L Šnajdrová, C Jeanneau, J Koča… - …, 2006 - academic.oup.com
Glycosyltransferases (GTs) catalyze the transfer of a sugar moiety from an activated donor
sugar onto saccharide and nonsaccharide acceptors. A sequence-based classification …

Structure of a fungal 1, 3-β-glucan synthase

CR Zhao, ZL You, DD Chen, J Hang, ZB Wang, M Ji… - Science …, 2023 - science.org
1, 3-β-Glucan serves as the primary component of the fungal cell wall and is produced by 1,
3-β-glucan synthase located in the plasma membrane. This synthase is a molecular target …

X-ray structure of a bacterial oligosaccharyltransferase

C Lizak, S Gerber, S Numao, M Aebi, KP Locher - Nature, 2011 - nature.com
Asparagine-linked glycosylation is a post-translational modification of proteins containing
the conserved sequence motif Asn-X-Ser/Thr. The attachment of oligosaccharides is …

Cellulose biosynthesis in plants: from genes to rosettes

MS Doblin, I Kurek, D Jacob-Wilk… - Plant and cell …, 2002 - academic.oup.com
Modern techniques of gene cloning have identified the CesA genes as encoding the
probable catalytic subunits of the plant CelS, the cellulose synthase enzyme complex …

Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity

D Gerlach, Y Guo, C De Castro, SH Kim, K Schlatterer… - Nature, 2018 - nature.com
Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of difficult-to-treat,
often fatal infections in humans,. Most humans have antibodies against S. aureus, but these …