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Challenges and opportunities in biological funneling of heterogeneous and toxic substrates beyond lignin
Significant developments in the understanding and manipulation of microbial metabolism
have enabled the use of engineered biological systems toward a more sustainable energy …
have enabled the use of engineered biological systems toward a more sustainable energy …
SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes
Abstract The SEVA platform (https://seva-plasmids. com) was launched one decade ago,
both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis …
both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis …
[HTML][HTML] An update on molecular tools for genetic engineering of actinomycetes—the source of important antibiotics and other valuable compounds
L Mitousis, Y Thoma, EM Musiol-Kroll - Antibiotics, 2020 - mdpi.com
The first antibiotic-producing actinomycete (Streptomyces antibioticus) was described by
Waksman and Woodruff in 1940. This discovery initiated the “actinomycetes era”, in which …
Waksman and Woodruff in 1940. This discovery initiated the “actinomycetes era”, in which …
Optimized De Novo Eriodictyol Biosynthesis in Streptomyces albidoflavus Using an Expansion of the Golden Standard Toolkit for Its Use in Actinomycetes
P Magadán-Corpas, S Ye, Á Pérez-Valero… - International Journal of …, 2023 - mdpi.com
Eriodictyol is a hydroxylated flavonoid displaying multiple pharmaceutical activities, such as
antitumoral, antiviral or neuroprotective. However, its industrial production is limited to …
antitumoral, antiviral or neuroprotective. However, its industrial production is limited to …
Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin
Á Pérez-Valero, S Ye, P Magadán-Corpas… - Microbial Cell …, 2023 - Springer
Flavonoids are important plant secondary metabolites showing antioxidant, antitumor, anti-
inflammatory, and antiviral activities, among others. Methylated flavonoids are particularly …
inflammatory, and antiviral activities, among others. Methylated flavonoids are particularly …
Systematic part transfer by extending a modular toolkit to diverse bacteria
It is impractical to develop a new parts collection for every potential host organism. It is well-
established that gene expression parts, like genes, are qualitatively transferable, but there is …
established that gene expression parts, like genes, are qualitatively transferable, but there is …
Biosynthesis of Hesperetin, Homoeriodictyol, and Homohesperetin in a Transcriptomics-Driven Engineered Strain of Streptomyces albidoflavus
Á Pérez-Valero, J Serna-Diestro… - International Journal of …, 2024 - mdpi.com
Flavonoids exhibit various bioactivities including anti-oxidant, anti-tumor, anti-inflammatory,
and anti-viral properties. Methylated flavonoids are particularly significant due to their …
and anti-viral properties. Methylated flavonoids are particularly significant due to their …
[HTML][HTML] Systems metabolic engineering of the primary and secondary metabolism of Streptomyces albidoflavus enhances production of the reverse antibiotic …
J Stegmüller, MR Estévez, W Shu, L Gläser… - Metabolic …, 2024 - Elsevier
Nybomycin is an antibiotic compound with proven activity against multi-resistant
Staphylococcus aureus, making it an interesting candidate for combating these globally …
Staphylococcus aureus, making it an interesting candidate for combating these globally …
De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3‐hydroxylase with 2‐hydroxylase side activity
L Marín, I Gutiérrez‐del‐Río, CJ Villar… - Microbial …, 2021 - Wiley Online Library
Flavonoids are important plant secondary metabolites, which were shown to have
antioxidant, anti‐inflammatory or antiviral activities. Heterologous production of flavonoids in …
antioxidant, anti‐inflammatory or antiviral activities. Heterologous production of flavonoids in …
Anti-capsule human monoclonal antibodies protect against hypervirulent and pandrug-resistant Klebsiella pneumoniae
The silent pandemic caused by antimicrobial resistance (AMR) requires innovative
therapeutic approaches. Human monoclonal antibodies (mAbs), which are among the most …
therapeutic approaches. Human monoclonal antibodies (mAbs), which are among the most …