The rapid evolution of gene editing technology has markedly improved the outlook for
treating genetic diseases. Base editing, recognized as an exceptionally precise genetic …

In 2022, sickle cell disease (SCD) continues to affect the lives of millions of people, being
one of the most frequently inherited blood disorders worldwide. Recently, several new …

Many sickle cell disease (SCD) patients lack matched family donors (MFD) or matched
unrelated donors (MUD), implying haploidentical donors (MMFD) as a logical donor choice …

Background: Patients with sickle cell disease (SCD) are exposed to numerous drugs over
their lifespan, and many of these drugs have Clinical Pharmacogenetics Implementation …

Sickle cell disease (SCD) is a prevalent condition, particularly in the countries of sub-
Saharan Africa, where the presence of specific genes associated with Malaria contributes to …

Hemoglobin is an oxygen-transport protein in red blood cells that interacts with multiple
ligands, eg, oxygen, carbon dioxide, carbon monoxide, and nitric oxide. Genetic variations in …

Sickle cell anemia (SCA) is an autosomal recessive Mendelian trait characterized by
symptoms that include acute and chronic pain, chest syndrome, pulmonary hypertension …

Introduction Children with sickle cell disease show a significant decrease in bone mineral
density, an increase in resting energy expenditure of more than 15%, a decrease in fat and …

Sickle cell diseases (SCD) are caused by a mutation in the β-globin gene that causes
deoxygenated hemoglobin to polymerize, resulting in rigid, fragile, sickle-shaped red blood …

Introduction Children with sickle cell disease show a significant decrease in bone mineral
density, an increase in resting energy expenditure of more than 15%, a decrease in fat and …