Targeting vascular (endothelial) dysfunction

A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases

D Del Rio, A Rodriguez-Mateos… - Antioxidants & redox …, 2013 - liebertpub.com
Human intervention trials have provided evidence for protective effects of various (poly)
phenol-rich foods against chronic disease, including cardiovascular disease …

Current evidence on the effect of dietary polyphenols intake on chronic diseases

C Costa, A Tsatsakis, C Mamoulakis, M Teodoro… - Food and Chemical …, 2017 - Elsevier
Polyphenols are secondary metabolites of plants. They comprise several antioxidant
compounds and they are generally considered to be involved in the defense against human …

Main drivers of (poly) phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

CE Iglesias-Aguirre, A Cortés-Martín… - Food & function, 2021 - pubs.rsc.org
Despite the high human interindividual variability in response to (poly) phenol consumption,
the cause-and-effect relationship between some dietary (poly) phenols (flavanols and olive …

[HTML][HTML] Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials

L Hooper, C Kay, A Abdelhamid, PA Kroon… - The American journal of …, 2012 - Elsevier
Background: There is substantial interest in chocolate and flavan-3-ols for the prevention of
cardiovascular disease (CVD). Objective: The objective was to systematically review the …

Is flow-mediated dilation nitric oxide mediated? A meta-analysis

DJ Green, EA Dawson, HMM Groenewoud, H Jones… - …, 2014 - Am Heart Assoc
Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular
health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this …

Cocoa and chocolate in human health and disease

DL Katz, K Doughty, A Ali - Antioxidants & redox signaling, 2011 - liebertpub.com
Cocoa contains more phenolic antioxidants than most foods. Flavonoids, including catechin,
epicatechin, and procyanidins predominate in antioxidant activity. The tricyclic structure of …

[HTML][HTML] Intake and time dependence of blueberry flavonoid–induced improvements in vascular function: a randomized, controlled, double-blind, crossover …

A Rodriguez-Mateos, C Rendeiro… - The American journal of …, 2013 - Elsevier
Background: There are very limited data regarding the effects of blueberry flavonoid intake
on vascular function in healthy humans. Objectives: We investigated the impact of blueberry …

Flavonoids and platelet aggregation: A brief review

C Faggio, A Sureda, S Morabito… - European journal of …, 2017 - Elsevier
Platelets are small anucleated fragments derived from a megakaryocyte precursor. Platelets
play a key role in many physiological functions especially in hemostasis and wound healing …