Improvements in genomic and molecular methods are expanding the range of potential
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …

Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract
cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of …

Nucleic acid sequence variations have been implicated in many diseases, and reliable
detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

With the development of new sensitive molecular techniques, circulating cell-free tumour
DNA containing mutations can be identified in the plasma of cancer patients. The …

Modern laboratory techniques for the detection of novel human viruses are greatly needed
as physicians and epidemiologists increasingly deal with infectious diseases caused by new …

Circulating tumor DNA (ctDNA) is a component of the “naked” DNA found in blood. It can be
isolated from plasma and represents combined genetic material from the primary tumor and …

Assessing circulating tumor DNA (ctDNA) is a promising method to evaluate somatic
mutations from solid tumors in a minimally-invasive way. In a group of twelve metastatic …

We demonstrate a unique parameter for biomolecule separation that results from the
nonlinear response of long, charged polymers to electrophoretic fields and apply it to …

We have developed a new separation device to concentrate and collect ions from several
milliliter sample volumes to microliter fractions. Unlike most conventional platforms, this …