LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Long non‐coding RNAs in development and disease: conservation to mechanisms

I Tsagakis, K Douka, I Birds… - The Journal of …, 2020 - Wiley Online Library
Our genomes contain the blueprint of what makes us human and many indications as to why
we develop disease. Until the last 10 years, most studies had focussed on protein‐coding …

RNAcentral 2021: secondary structure integration, improved sequence search and new member databases

Nucleic acids research, 2021 - academic.oup.com
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that
provides a single access point to 44 RNA resources and> 18 million ncRNA sequences from …

[HTML][HTML] Estrogenic control of mitochondrial function

CM Klinge - Redox biology, 2020 - Elsevier
Sex-based differences in human disease are caused in part by the levels of endogenous
sex steroid hormones which regulate mitochondrial metabolism. This review updates a …

Mitochondrial dysfunction in cardiovascular diseases: potential targets for treatment

J Yang, Q Guo, X Feng, Y Liu, Y Zhou - Frontiers in cell and …, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are serious public health issues and are responsible for
nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the …

ADPGK‐AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth

A Karger, S Mansouri, MS Leisegang, A Weigert… - The EMBO …, 2023 - embopress.org
Long noncoding RNAs (lncRNAs) influence the transcription of gene networks in many cell
types, but their role in tumor‐associated macrophages (TAMs) is still largely unknown. We …

Functional role of mitochondrial DNA in cancer progression

YH Lin, SN Lim, CY Chen, HC Chi, CT Yeh… - International journal of …, 2022 - mdpi.com
Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in
disease, cancer and evolution. Mitochondria function as modulators for regulating cellular …

[HTML][HTML] Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease

T Braun, KE Sosnovski, A Amir, M BenShoshan… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Ulcerative colitis (UC), Crohn's disease (CD), and celiac disease are prevalent
intestinal inflammatory disorders with nonsatisfactory therapeutic interventions. Analyzing …

The crucial role of AR-V7 in enzalutamide-resistance of castration-resistant prostate cancer

Z Zheng, J Li, Y Liu, Z Shi, Z Xuan, K Yang, C Xu, Y Bai… - Cancers, 2022 - mdpi.com
Simple Summary Androgen receptor splice variant 7 (AR-V7) has always been considered a
key driver for triggering enzalutamide resistance of castration-resistant prostate cancer …

Genetic basis of mitochondrial diseases

M Gusic, H Prokisch - FEBS letters, 2021 - Wiley Online Library
Mitochondrial disorders are monogenic disorders characterized by a defect in oxidative
phosphorylation and caused by pathogenic variants in one of over 340 different genes. The …