Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …

Fungal infection poses a major global threat to public health because of its wide prevalence,
severe mortality rate, challenges involved in diagnosis and treatment, and the emergence of …

This paper describes the development of poly (D, L-lactide-co-glycolide)(PLGA)
nanoparticles (NPs) and nanosuspensions with the polyene antibiotic amphotericin B …

The effect of chemotherapy for anti-glioblastoma is limited due to insufficient drug delivery
across the blood–brain–barrier. Poloxamer 188-coated nanoparticles can enhance the …

Antifungal drugs such as amphotericin B (AmB) interact with lipids and phospholipids
located on fungal cell membranes to disrupt them and create pores, leading to cell apoptosis …

Amphotericin B (AmB) loaded polymer lipid hybrid nanoparticles (AmB-PLNs) comprised of
lecithin (anionic lipid) and gelatin (Type A, cationic below its isoelectric point 7.0–9.0) were …

Invasive fungal infections can be devastating, particularly in immunocompromised patients,
and difficult to treat with systemic drugs. Furthermore, systemic administration of those …

This study describes the properties of an amphotericin B-containing mucoadhesive
nanostructured lipid carrier (NLC), with the intent to maximize uptake within the …

Amphotericin B (AmB) is a broad-spectrum antifungal drug used in the treatment of fungal
invasive infections. However, its clinical use has been limited due to its side effects and …

Parenteral amphotericin B has been considered as first-line therapy in the treatment of
systemic fungal and parasitic infections, however its use has been associated with a number …