Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia
E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …
preterm infants. A key histopathological feature of BPD is stunted late lung development …
Congenital diaphragmatic hernia-associated pulmonary hypertension
Congenital diaphragmatic hernia (CDH) is a neonatal pathology in which intrathoracic
herniation of abdominal viscera via diaphragmatic defect results in aberrant pulmonary and …
herniation of abdominal viscera via diaphragmatic defect results in aberrant pulmonary and …
Bronchopulmonary dysplasia: an update of current pharmacologic therapies and new approaches
Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of
surviving extremely preterm infants and is associated with significant health care utilization …
surviving extremely preterm infants and is associated with significant health care utilization …
Rescuing lung development through embryonic inhibition of histone acetylation
G Stokes, Z Li, N Talaba, W Genthe, MB Brix… - Science Translational …, 2024 - science.org
A major barrier to the impact of genomic diagnosis in patients with congenital malformations
is the lack of understanding regarding how sequence variants contribute to disease …
is the lack of understanding regarding how sequence variants contribute to disease …
Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect,
has been investigated concerning various conditions during pregnancy. Per indication, we …
has been investigated concerning various conditions during pregnancy. Per indication, we …
[HTML][HTML] Cellular origins and translational approaches to congenital diaphragmatic hernia
Abstract Congenital Diaphragmatic Hernia (CDH) is a complex developmental abnormality
characterized by abnormal lung development, a diaphragmatic defect and cardiac …
characterized by abnormal lung development, a diaphragmatic defect and cardiac …
Pulmonary hypertension secondary to congenital diaphragmatic hernia: factors and pathways involved in pulmonary vascular remodeling
Congenital diaphragmatic hernia (CDH) is a severe birth defect that is characterized by
pulmonary hypoplasia and pulmonary hypertension (PHTN). PHTN secondary to CDH is a …
pulmonary hypoplasia and pulmonary hypertension (PHTN). PHTN secondary to CDH is a …
Placental effects and transfer of sildenafil in healthy and preeclamptic conditions
Background The phosphodiesterase-5 inhibitor (PDE5) sildenafil has emerged as a
promising treatment for preeclampsia (PE). However, a sildenafil trial was recently halted …
promising treatment for preeclampsia (PE). However, a sildenafil trial was recently halted …
Prenatal treprostinil reduces the pulmonary hypertension phenotype in the rat model of congenital diaphragmatic hernia
FR De Bie, CG Halline, T Kotzur, K Hayes, CC Rouse… - …, 2022 - thelancet.com
Background Persistent pulmonary hypertension (PH) causes significant mortality and
morbidity in infants with congenital diaphragmatic hernia (CDH). Since pulmonary vascular …
morbidity in infants with congenital diaphragmatic hernia (CDH). Since pulmonary vascular …
Antenatal sildenafil treatment improves neonatal pulmonary hemodynamics and gas exchange in lambs with diaphragmatic hernia
AJ Kashyap, PLJ Dekoninck… - … in Obstetrics & …, 2019 - Wiley Online Library
Objectives Infants with congenital diaphragmatic hernia (CDH) are predisposed to
pulmonary hypertension after birth, owing to lung hypoplasia that impairs fetal pulmonary …
pulmonary hypertension after birth, owing to lung hypoplasia that impairs fetal pulmonary …