This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency Medicine 2019. Other selected articles can be found online at https://www …

Background Sepsis causes multiple organ dysfunctions and raises mortality and morbidity
rates through a dysregulated host response to infection. Despite the growing research …

Objectives: This study sought to examine mortality, health-related quality of life, and physical
function among sepsis survivors who developed chronic critical illness. Design: Single …

Objectives: Our goal was to “reverse translate” the human response to surgical sepsis into
the mouse by modifying a widely adopted murine intra-abdominal sepsis model to engender …

Sepsis‐related mortality rates are high among elderly patients, especially those in intensive
care units (ICUs). Early prediction of the prognosis of sepsis is critical, as prompt and …

Purpose To investigate age-related differences in outcomes of critically ill patients with
sepsis around the world. Methods We performed a secondary analysis of data from the …

The wide use of the mouse model of polymicrobial sepsis has provided important evidence
for events occurring in infectious sepsis involving septic mice and septic humans. Nearly …

Globally, sepsis and pneumonia account for significant mortality and morbidity. A complex
interplay of immune-molecular pathways underlies both sepsis and pneumonia, resulting in …

Although in-hospital mortality rates for sepsis have decreased, survivors often experience
lasting physical and cognitive deficits. Moreover, older adults are more vulnerable to long …

Extremity and soft tissue injuries contribute significantly to inflammation and adverse in-
hospital outcomes for trauma survivors; accordingly, we examined the complex association …