The thalamus is a small, bilateral structure in the diencephalon that integrates signals from
many areas of the CNS. This critical anatomical position allows the thalamus to influence …

Standard models of episodic memory focus on hippocampal–parahippocampal interactions,
with the neocortex supplying sensory information and providing a final repository of …

The thalamus is globally connected with distributed cortical regions, yet the functional
significance of this extensive thalamocortical connectivity remains largely unknown. By …

It is widely assumed that incipient protein pathology in the medial temporal lobe instigates
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …

Executive control, the ability to organize thoughts and action plans in real time, is a defining
feature of higher cognition. Classical theories have emphasized cortical contributions to this …

The function of the human mediodorsal thalamic nucleus (MD) has so far eluded a clear
definition in terms of specific cognitive processes and tasks. Although it was at first proposed …

Background: Alzheimer's disease (AD) is characterized by cognitive impairment and large
loss of grey matter volume and is the most prevalent form of dementia worldwide. Mild …

The anterior thalamic nuclei are a vital node within hippocampal-diencephalic-cingulate
circuits that support spatial learning and memory. Reflecting this interconnectivity, the …

After more than 80 years, Papez serial circuit remains a hugely influential concept, initially
for emotion, but in more recent decades, for memory. Here, we show how this circuit is …

The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of
the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron …