Research in the development of ophthalmic drug formulations and innovative technologies
over the past few decades has been directed at improving the penetration of medications …

Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to
induce pathology in age-dependent neurodegenerations. However, emerging evidence …

Importance Open-angle glaucoma may continue to progress despite significant lowering of
intraocular pressure (IOP). Preclinical research has suggested that enhancing mitochondrial …

Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
map** of visual sensitivity and measurement of fixation stability, both in clinical practice as …

Energy metabolism refers to the processes by which life transfers energy to do cellular work.
The retina's relatively large energy demands make it vulnerable to energy insufficiency. In …

The cholinergic system has a crucial role to play in visual function. Although cholinergic
drugs have been a focus of attention as glaucoma medications for reducing eye pressure …

Glaucoma is a result of irreversible damage to the retinal ganglion cells. While an early
intervention could minimise the risk of vision loss in glaucoma, its asymptomatic nature …

Abstract By 2040,~ 100 million people will have glaucoma. To date, there are a lack of high-
efficiency glaucoma diagnostic tools based on visual fields (VFs). Herein, we develop and …

Dysregulation of the complement system is implicated in neurodegeneration, including
human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by …

This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-
apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in in vitro, in vivo, and ex vivo …