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The endocrine function of adipose tissues in health and cardiometabolic disease
In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …
Inter-organ cross-talk in metabolic syndrome
Maintenance of systemic homeostasis and the response to nutritional and environmental
challenges require the coordination of multiple organs and tissues. To respond to various …
challenges require the coordination of multiple organs and tissues. To respond to various …
Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure
Tissue-tissue communication by endocrine factors is a vital mechanism for physiologic
homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort …
homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort …
High-throughput spatiotemporal monitoring of single-cell secretions via plasmonic microwell arrays
Methods for the analysis of cell secretions at the single-cell level only provide
semiquantitative endpoint readouts. Here we describe a microwell array for the real-time …
semiquantitative endpoint readouts. Here we describe a microwell array for the real-time …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
A mechanistic framework for cardiometabolic and coronary artery diseases
Coronary atherosclerosis results from the delicate interplay of genetic and exogenous risk
factors, principally taking place in metabolic organs and the arterial wall. Here we show that …
factors, principally taking place in metabolic organs and the arterial wall. Here we show that …
Inter‐organ communication: a gatekeeper for metabolic health
Multidirectional interactions between metabolic organs in the periphery and the central
nervous system have evolved concomitantly with multicellular organisms to maintain whole …
nervous system have evolved concomitantly with multicellular organisms to maintain whole …
Human plasma proteomic profiles indicative of cardiorespiratory fitness
Maximal oxygen uptake (VO2max) is a direct measure of human cardiorespiratory fitness
and is associated with health. However, the molecular determinants of interindividual …
and is associated with health. However, the molecular determinants of interindividual …
Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens
D Wang, L Tan, Y Zhi, L Bu, Y Wang, Z Wang… - Nature …, 2024 - nature.com
Egg-laying performance is of great economic importance in poultry, but the underlying
genetic mechanisms are still elusive. In this work, we conduct a multi-omics and multi-tissue …
genetic mechanisms are still elusive. In this work, we conduct a multi-omics and multi-tissue …
Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
Secretory proteins are an essential component of interorgan communication networks that
regulate animal physiology. Current approaches for identifying secretory proteins from …
regulate animal physiology. Current approaches for identifying secretory proteins from …