Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a
diversity of cellular processes during development but also plays a pivotal role in …

14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-
protein interactions (PPIs). They are usually found in all eukaryotes with a conserved …

14-3-3σ is an acidic homodimer protein with more than one hundred different protein
partners associated with oncogenic signaling and cell cycle regulation. This review aims to …

Spatiotemporally dynamic microtubule acetylation underlies diverse physiological and
pathological events. Despite its ubiquity, the molecular mechanisms that regulate the sole …

1, 25-Dihydroxyvitamin D3 (1, 25-(OH) 2D3), inhibits proliferation of a variety of cell types
including adenocarcinoma of the prostate. We have previously shown that 1, 25-(OH) 2D3 …

An in silico structure-based ligand design approach resulted in the identification of the first
non-peptidic small molecule able to inhibit protein–protein interactions between 14-3-3 and …

Targeting the binding site of 14-3-3 proteins lets the release of partner proteins involved in
cell cycle progression, apoptosis, cytoskeletal rearrangement and transcriptional regulation …

Cell migration is an essential process of cancer metastasis. The spatiotemporal dynamics of
signaling molecules influences cellular phenotypic outcomes. It has been increasingly …

Bruton's tyrosine kinase (Btk) is crucial for B-lymphocyte activation and development.
Mutations in the Btk gene cause X-linked agammaglobulinemia (XLA) in humans and X …

Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor with limited
treatment options and poor prognosis. In this study, we reveal the pivotal role of Stratifin …