Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Studies of 3D chromatin organization have suggested that chromosomes are hierarchically
organized into large compartments composed of smaller domains called topologically …

Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …

Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …

Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …

Over the past decade, 3C-related methods have provided remarkable insights into
chromosome folding in vivo. To overcome the limited resolution of prior studies, we extend a …

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …

Nucleosome positioning varies between cell types. By deep sequencing cell-free DNA
(cfDNA), isolated from circulating blood plasma, we generated maps of genome-wide in vivo …

CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …

How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …