Adaptive optics (AO) is a technique that corrects for optical aberrations. It was originally
proposed to correct for the blurring effect of atmospheric turbulence on images in ground …

In the realm of biological research, the invention of super-resolution microscopy (SRM) has
enabled the visualization of ultrafine sub-cellular structures and their functions in live cells at …

Fluorescence microscopy has become a ubiquitous method to observe the location of
specific molecular components within cells. However, the resolution of light microscopy is …

Molecular photoswitches transform light energy into reversible structural changes. Their
combination with known pharmacophores often allows for photomodulation of the biological …

The optical microscope has revolutionized biology since at least the 17th Century. Since
then, it has progressed from a largely observational tool to a powerful bioanalytical platform …

Although the concept of selective delivery has been postulated over 100 years ago, no
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …

The maker movement has reached the optics labs, empowering researchers to create and
modify microscope designs and imaging accessories. 3D printing has a disruptive impact on …

Biological tissues are not uniquely composed of cells. A substantial part of their volume is
extracellular space, which is primarily filled by an intricate network of macromolecules …

Mitochondria are essential for eukaryotic life. These double-membrane organelles often
form highly dynamic tubular networks interacting with many cellular structures. Their highly …

Fluorogenic probes efficiently reduce non-specific background signals, which often results in
highly improved signal-to-noise ratios. Although this implies improved resolution …