Cyanobacteria as cell factories: the roles of host and pathway engineering and translational research
Highlights•Host organisms need to tolerate outdoor conditions and abiotic stresses.•Robust,
fast-growing cyanobacterial strains can be engineered as efficient hosts.•Engineered and …
fast-growing cyanobacterial strains can be engineered as efficient hosts.•Engineered and …
In Silico Constraint-Based Strain Optimization Methods: the Quest for Optimal Cell Factories
Shifting from chemical to biotechnological processes is one of the cornerstones of 21st
century industry. The production of a great range of chemicals via biotechnological means is …
century industry. The production of a great range of chemicals via biotechnological means is …
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0
Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …
framework for integrative analysis of experimental molecular systems biology data and …
Bilevel optimization: theory, algorithms, applications and a bibliography
S Dempe - Bilevel optimization: advances and next challenges, 2020 - Springer
Bilevel optimization problems are hierarchical optimization problems where the feasible
region of the so-called upper level problem is restricted by the graph of the solution set …
region of the so-called upper level problem is restricted by the graph of the solution set …
[KNJIGA][B] Bilevel optimization: theory, algorithms and applications
S Dempe - 2018 - optimization-online.org
Bilevel optimization problems are hierarchical optimization problems where the feasible
region of the so-called upper level problem is restricted by the graph of the solution set …
region of the so-called upper level problem is restricted by the graph of the solution set …
Metabolic engineering of Synechococcus elongatus 7942 for enhanced sucrose biosynthesis
The capability of cyanobacteria to produce sucrose from CO 2 and light has a remarkable
societal and biotechnological impact since sucrose can serve as a carbon and energy …
societal and biotechnological impact since sucrose can serve as a carbon and energy …
[HTML][HTML] Computational metabolic engineering strategies for growth-coupled biofuel production by Synechocystis
Chemical and fuel production by photosynthetic cyanobacteria is a promising technology but
to date has not reached competitive rates and titers. Genome-scale metabolic modeling can …
to date has not reached competitive rates and titers. Genome-scale metabolic modeling can …
A comprehensive genome-scale model for Rhodosporidium toruloides IFO0880 accounting for functional genomics and phenotypic data
Rhodosporidium toruloides is a red, basidiomycetes yeast that can accumulate a large
amount of lipids and produce carotenoids. To better assess this non-model yeast's metabolic …
amount of lipids and produce carotenoids. To better assess this non-model yeast's metabolic …
Designing overall stoichiometric conversions and intervening metabolic reactions
Existing computational tools for de novo metabolic pathway assembly, either based on
mixed integer linear programming techniques or graph-search applications, generally only …
mixed integer linear programming techniques or graph-search applications, generally only …
Improving prediction fidelity of cellular metabolism with kinetic descriptions
Highlights•Kinetic model developments are reviewed.•Integration of elementary
mechanisms with ensemble parameter sampling techniques is detailed.•Integration of …
mechanisms with ensemble parameter sampling techniques is detailed.•Integration of …