The metabolic syndrome, a human disease

M Alemany - International journal of molecular sciences, 2024 - mdpi.com
This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

Adiponectin regulation and function

H Fang, RL Judd - Comprehensive Physiology, 2011 - Wiley Online Library
Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Expansible residence decentralizes immune homeostasis

S Wijeyesinghe, LK Beura, MJ Pierson, JM Stolley… - Nature, 2021 - nature.com
In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

Hepatic ischemia/reperfusion: mechanisms of tissue injury, repair, and regeneration

T Konishi, AB Lentsch - Gene expression, 2017 - pmc.ncbi.nlm.nih.gov
Hepatic ischemia/reperfusion (I/R) injury is a major complication of liver surgery, including
liver resection, liver transplantation, and trauma surgery. Much has been learned about the …

Asthma: from bronchoconstriction to airways inflammation and remodeling

J Bousquet, PK Jeffery, WW Busse… - American journal of …, 2000 - atsjournals.org
Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Blood-brain barrier tight junction permeability and ischemic stroke

KE Sandoval, KA Witt - Neurobiology of disease, 2008 - Elsevier
The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels,
providing a dynamic interface between the peripheral circulation and the central nervous …

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation

PR Kvietys, DN Granger - Free Radical Biology and Medicine, 2012 - Elsevier
Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning

H Jaeschke - American Journal of Physiology …, 2003 - journals.physiology.org
Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with
liver surgery under total vascular exclusion or after liver transplantation. The …

The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair

B Vollmar, MD Menger - Physiological reviews, 2009 - journals.physiology.org
The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Neutrophils in development of multiple organ failure in sepsis

KA Brown, SD Brain, JD Pearson, JD Edgeworth… - The Lancet, 2006 - thelancet.com
Multiple organ failure is a major threat to the survival of patients with sepsis and systemic
inflammation. In the UK and in the USA, mortality rates are currently comparable with and …