To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

There are three major subfamilies of mitogen-activated protein kinases (MAPK): the
extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress …

Phosphodiesterase 5 (PDE5) inhibitors presented themselves as important players in the
nitric oxide/cGMP pathway, thus exerting a profound impact on various physiological and …

The regular use of various nonsteroidal anti‐inflammatory drugs (NSAIDs) was shown to
decrease the incidence of colorectal cancer. This effect is thought to be caused …

Nitric oxide (NO), synthesized from L-arginine by NO synthases, is a small, lipophilic,
diffusible, highly reactive molecule with dichotomous regulatory roles in many biological …

Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs
(NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of …

Epidemiological studies link increased garlic (Allium sativum) consumption with a reduced
incidence of colon cancer in various human populations. Experimental carcinogenesis …

Epidemiological and experimental carcinogenesis studies provide evidence that
components of garlic (Allium sativum) have anticancer activity. We recently reported that the …

The effects of Escherichia coli heat-stable enterotoxin (ST) and uroguanylin were examined
on the proliferation of T84 and Caco2 human colon carcinoma cells that express guanylyl …

Antimitotic agents have generated considerable interest among cytotoxic agents due to the
tremendous success of the taxanes and the widespread use of the Vinca alkaloids in clinical …