Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta
and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps …

Background Redox imbalance and inflammation have been proposed as the principal
mechanisms of damage in the auditory system, resulting in functional alterations and …

Age-related macular degeneration (AMD) is a prevalent degenerative disorder of the central
retina, which holds global significance as the fourth leading cause of blindness. The …

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-beta (Aβ)
plaques, neurofibrillary tangles (NFTs) formed from hyperphosphorylated Tau, and …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder and the leading cause
of age-related cognitive decline. Recent studies have established a close relationship …

Regulation of autophagy through the 62 kDa ubiquitin-binding protein/autophagosome
cargo protein sequestosome 1 (p62/SQSTM1), whose level is generally inversely …

In neurodegenerative diseases, the activation of microglia and the ensuing
neuroinflammation are pivotal in regulating disease progression. Attenuating inflammation …

Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is
characterized by neurological impairments such as visual and sensory difficulties, motor …

Vitamin A (retinol) and its derivatives (retinoids) assume critical roles in neural development,
cellular differentiation, axon elongation, programmed cell apoptosis and various …