The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Legionella species are environmental gram-negative bacteria able to cause a severe form of
pneumonia in humans known as Legionnaires' disease. Since the identification of …

We previously reported that Parkinson's disease (PD) kinase LRRK2 phosphorylates a
subset of Rab GTPases on a conserved residue in their switch-II domains (Steger et al …

The intracellular bacterial pathogen Legionella pneumophila modulates host cell functions
by secreting multiple effectors with diverse biochemical activities. In particular, effectors of …

Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Several of the most important discoveries in the field of membrane traffic have come from
studies of Rab GTPases by Marino Zerial and Peter Novick and their colleagues. Zerial was …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular
pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host …

Abbreviations used in this paper: ANOVA, analysis of variance; FKBP, FK506 binding
protein; FRB, FKBP12-rapamycin binding; iRFP, infra-RFP; nMDP, normalized mean …

In plants, host response to pathogenic microbes is driven both by microbial perception and
detection of modified-self. The Xanthomonas campestris effector protein AvrAC/XopAC …