Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Cancer is a complex disease since it is adaptive in such a way that it can promote
proliferation and invasion by means of an overactive cell cycle and in turn cellular division …

Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Despite the huge investment into research and the significant effort and advances made in
the search for new anticancer drugs in recent decades, cancer cure and treatment continue …

The microtubule (MT) associated protein tau, which is highly expressed in the axons of
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …

Covering: up to June 2006This review article provides an overview on the current state of
research in the area of microtubule-stabilizing agents from natural sources, with a primary …

Drugs that affect microtubule dynamics, including the taxanes and vinca alkaloids, have
been a mainstay in the treatment of leukemias and solid tumors for decades. New, more …