A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials

Q Gong, J Hu, P Wang, X Li, X Zhang - European Journal of Medicinal …, 2021 - Elsevier
Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Anticancer potential of resveratrol, β-lapachone and their analogues

DC Ferraz da Costa, L Pereira Rangel… - Molecules, 2020 - mdpi.com
This review aims to explore the potential of resveratrol, a polyphenol stilbene, and beta-
lapachone, a naphthoquinone, as well as their derivatives, in the development of new drug …

Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination

L Dunsmore, CD Navo, J Becher, EG de Montes… - Nature Chemistry, 2022 - nature.com
Natural products that contain ortho-quinones show great potential as anticancer agents but
have been largely discarded from clinical development because their redox-cycling …

Increasing the polarity of β-lapachone does not affect its binding capacity with bovine plasma protein

OA Chaves, RJS Loureiro, C Serpa, PF Cruz… - International Journal of …, 2024 - Elsevier
Despite ortho-quinones showing several biological and pharmacological activities, there is
still a lack of biophysical characterization of their interaction with albumin-the main carrier of …

[HTML][HTML] Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

Z **ao, Y Gu, H Dong, B Liu, W **, J Li, P Ma… - European Journal of …, 2023 - Elsevier
Natural products play a key role in the history of human drug discovery, and especially for
the anticancer agents. Copper (I)-catalyzed alkyne-azide [3+ 2] cycloaddition (CuAAC) …

Natural naphthoquinones and their derivatives as potential drug molecules against trypanosome parasites

R Rani, K Sethi, S Kumar, RS Varma… - Chemical Biology & …, 2022 - Wiley Online Library
Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

Recent Developments in the Ruthenium‐Catalyzed Azide Alkyne Cycloaddition (RuAAC) Reaction

F Ferrara, T Beke‐Somfai… - European Journal of …, 2024 - Wiley Online Library
The ruthenium‐catalyzed azide‐alkyne cycloaddition (RuAAC) gives access to 1, 5‐
disubstitued triazoles in a single atom‐economical step and offers advantages compared to …

Electrochemical selenation/cyclization of quinones: a rapid, green and efficient access to functionalized trypanocidal and antitumor compounds

A Kharma, C Jacob, ÍAO Bozzi… - European Journal of …, 2020 - Wiley Online Library
Electrochemical selenation in undivided electrochemical cells allows the preparation of
selenium‐containing naphthoquinones. The rapid, green and efficient protocol avoids …

Selenoneine-inspired selenohydantoins with glutathione peroxidase-like activity

R Alhasan, GM Martins, PP de Castro… - Bioorganic & Medicinal …, 2023 - Elsevier
Chronic diseases such as cystic fibrosis, inflammatory bowel diseases, rheumatoid arthritis,
and cardiovascular illness have been linked to a decrease in selenium levels and an …

Quinone-based molecular electrochemistry and their contributions to medicinal chemistry: A look at the present and future

TL Silva, SG Maria de Lourdes, FR Ferreira… - Current Opinion in …, 2020 - Elsevier
Molecular electrochemistry is closely linked to life sciences. Electron transfers play important
roles in the bioactivation of redox-active drugs, in their metabolism/catabolism, and in their …