Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …

Background Effective targeted therapy for sepsis requires an understanding of the
heterogeneity in the individual host response to infection. We investigated this heterogeneity …

Alphaviruses are a large group of re-emerging arthropod-borne RNA viruses. The compact
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …

Whereas type I interferons (IFNs) have critical roles in protection from pathogens, excessive
IFN responses contribute to pathology in both acute and chronic settings, pointing to the …

DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to
the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family …

DExH/D-box helicases are essential nucleic acid and ribonucleoprotein remodelers
involved in all aspects of nucleic acid metabolism including replication, gene expression …

Abstract DEAD/H-box RNA helicases make the prominent family of helicases super family-2
which take part in almost all RNA-related processes, from initiation of transcription to RNA …

Type I IFNs (α, β, and others) are a family of cytokines that are produced in physiological
conditions as well as in response to the activation of pattern recognition receptors. They are …

DExD/H-box helicases play critical roles in multiple cellular processes, including
transcription, cellular RNA metabolism, translation, and infections. Several seminal studies …