Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Reactive crystallization is not new, but there has been recent growth in its use as a means of
improving performance and sustainability of industrial processes. This review examines …

Synthesis planning programs trained on chemical reaction data can design efficient routes
to new molecules of interest, but are limited in their ability to leverage rare chemical …

Introduction Nucleoside analogues represent a cornerstone of achievement in drug
discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery …

Great pioneers of nucleic acid chemistry had elucidated nucleic acid functions and
structures and developed various antiviral modified nucleoside drugs. It is possible in theory …

Acquired immunodeficiency syndrome (AIDS) is caused by infection with the human
immunodeficiency virus (HIV). Although treatments against HIV infection are available, AIDS …

β-Nucleosides are fundamental building blocks of biological systems and are widely used
as therapeutic agents for the treatment of cancer and viral infections, among others. In the …

C4ʹ-modified nucleoside analogues continue to attract global attention for their use in
antiviral drug development and oligonucleotide-based therapeutics. However, current …

4′-Selective alkylation of nucleosides has been recognized as one of the ideal and
straightforward approaches to chemically modified nucleosides, but such a transformation …

Research on coordination polymers (CPs) using 2-deoxy-d-ribose derivatives as ligands
has not been documented to the best of our knowledge. Herein, the new ligand L (1, 3, 4 …