Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-
inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation …

Cancer and neurodegeneration are different classes of diseases that share the involvement
of mitochondria in their pathogenesis. Whereas the high glycolytic rate (the so-called …

Fucoxanthin, a natural product of carotenoids, is a potential drug source obtained from
marine algae. The special chemical structure of fucoxanthin has equipped it with a variety of …

Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the
existing ones, playing critical roles in physiological and pathological processes such as …

Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …

The transformation of normal cells to the cancerous stage involves multiple genetic changes
or mutations leading to hyperproliferation, resistance to apoptosis, and evasion of the host …

ABSTRACT Macroautophagy/autophagy (hereafter autophagy), the process of mass
degradation of unnecessary elements within the cell, is often dysregulated in many diseases …

The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the
outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion …

Angiogenesis plays important roles in development, stress response, wound healing,
tumorigenesis and cancer progression, diabetic retinopathy, and age-related macular …