The metabolic nature of inflammatory bowel diseases

TE Adolph, M Meyer, J Schwärzler, L Mayr… - Nature Reviews …, 2022 - nature.com
Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

Western diets and chronic diseases

TE Adolph, H Tilg - Nature medicine, 2024 - nature.com
Abstract 'Westernization', which incorporates industrial, cultural and dietary trends, has
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …

Challenges and opportunities in sharing microbiome data and analyses

C Huttenhower, RD Finn, AC McHardy - Nature Microbiology, 2023 - nature.com
Microbiome data, metadata and analytical workflows have become 'big'in terms of volume
and complexity. Although the infrastructure and technologies to share data have been …

Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective

M Valles-Colomer, C Menni, SE Berry, AM Valdes… - Nature Medicine, 2023 - nature.com
Cardiometabolic diseases have become a leading cause of morbidity and mortality globally.
They have been tightly linked to microbiome taxonomic and functional composition, with diet …

Conditioning of the immune system by the microbiome

DB Graham, RJ Xavier - Trends in Immunology, 2023 - cell.com
The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …

Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts

TE Adolph, J Zhang - Gut, 2022 - gut.bmj.com
The diet and gut microbiota have been extensively interrogated as a fuel for gut
inflammation in inflammatory bowel diseases (IBDs) in the last few years. Here, we review …

Dubosiella newyorkensis modulates immune tolerance in colitis via the L-lysine-activated AhR-IDO1-Kyn pathway

Y Zhang, S Tu, X Ji, J Wu, J Meng, J Gao… - Nature …, 2024 - nature.com
Commensal bacteria generate immensely diverse active metabolites to maintain gut
homeostasis, however their fundamental role in establishing an immunotolerogenic …

Near-infrared-II-driven pollen micromotors for inflammatory bowel disease treatment

L Cai, X Cao, C Zhao, Z Luo, Y Zhao - ACS nano, 2023 - ACS Publications
Inflammatory bowel disease (IBD) is a common inflammatory bowel disease with a high
incidence rate and serious consequences. Attempts in this area are focusing on develo** …

Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme

M Bae, C Le, RS Mehta, X Dong, LM Pieper… - Cell host & …, 2024 - cell.com
Gut microbial catechol dehydroxylases are a largely uncharacterized family of
metalloenzymes that potentially impact human health by metabolizing dietary polyphenols …

Pollen‐Inspired Adhesive Multilobe Microparticles from Microfluidics for Intestinal Drug Delivery

D Huang, J Wang, M Nie, G Chen… - Advanced Materials, 2023 - Wiley Online Library
Microparticles (MPs)‐based delivery systems have a demonstrated value in gastrointestinal
administration. Research in this area is focusing on the development of multifunctional MPs …