The sodium-glucose cotransporter 2 (SGLT2) is a glucose transporter that is located within
the proximal tubule of the kidney's nephrons. While it is typically associated with the kidney …

In health, the glucose concentration of airway surface liquid (ASL) is 0.4 mM, about 12 times
lower than the blood glucose concentration. Airway glucose homeostasis comprises a set of …

Monitoring of blood glucose is an invasive, painful and costly practice in diabetes.
Consequently, the search for a more cost-effective (reagent-free), non-invasive and specific …

In drug development, a major reason for attrition is the lack of understanding of cellular
mechanisms governing drug toxicity. The black-box nature of conventional classification …

Background Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New
therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium …

Background Epidemiological studies have demonstrated that individuals with preexisting
conditions, including diabetes mellitus (DM), are more susceptible to air pollution. However …

Two-thirds of patients with diabetes avoid regularly monitoring their blood glucose levels
because of the painful and invasive nature of current blood glucose detection. As an …

Bacterial and viral co-infections of the respiratory tract are life-threatening and present a
global burden to the global community. Staphylococcus aureus, Streptococcus pneumoniae …

The expression and localization of sodium-d-glucose cotransporter SGLT1 (SLC5A1), which
is involved in small intestinal glucose absorption and renal glucose reabsorption, is of high …

Background Diabetes mellitus causes the deterioration of smooth muscle cells and
interstitial matrix proteins, including collagen. Collagen and smooth muscle cells are …