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[HTML][HTML] Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy
Viral malignancies represent a distinct entity among cancers. Oncoviruses like the Human
Papilloma Virus (HPV) and the Epstein Barr Virus (EBV) are highly potent inducers of …
Papilloma Virus (HPV) and the Epstein Barr Virus (EBV) are highly potent inducers of …
Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning
Non-invasive imaging methods for detecting intratumoural viral spread and host responses
to oncolytic virotherapy are either slow, lack specificity or require the use of radioactive or …
to oncolytic virotherapy are either slow, lack specificity or require the use of radioactive or …
[PDF][PDF] Nitroxoline: repurposing its antimicrobial to antitumor application
Cancer is a disease receiving an outstanding input of funds for basic and clinical research
but is, nevertheless, still the second leading cause of death in the developed world and a …
but is, nevertheless, still the second leading cause of death in the developed world and a …
Pre-treatment amide proton transfer imaging predicts treatment outcome in nasopharyngeal carcinoma
Objective To investigate the value of pre-treatment amide proton transfer–weighted (APTw)
imaging for predicting survival of patients with nasopharyngeal carcinoma (NPC). Materials …
imaging for predicting survival of patients with nasopharyngeal carcinoma (NPC). Materials …
Anatomic and molecular MR image synthesis using confidence guided CNNs
Data-driven automatic approaches have demonstrated their great potential in resolving
various clinical diagnostic dilemmas in neuro-oncology, especially with the help of standard …
various clinical diagnostic dilemmas in neuro-oncology, especially with the help of standard …
Differentiation of meningiomas and gliomas by amide proton transfer imaging: a preliminary study of brain tumour infiltration
HW Zhang, XL Liu, HB Zhang, YQ Li, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Background Gliomas are more malignant and invasive than meningiomas. Objective To
distinguish meningiomas from low-grade/high-grade gliomas (LGGs/HGGs) using amide …
distinguish meningiomas from low-grade/high-grade gliomas (LGGs/HGGs) using amide …
APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage
Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw)
MRI in three different rodent models of hepatocellular carcinoma (HCC). Methods: APTw …
MRI in three different rodent models of hepatocellular carcinoma (HCC). Methods: APTw …
Evaluation of temozolomide treatment for glioblastoma using amide proton transfer imaging and diffusion MRI
R Onishi, R Sawaya, K Tsuji, N Arihara, A Ohki, J Ueda… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM), the most frequent and malignant histological type of
glioma, is associated with a very high mortality rate. MRI is a useful method for the …
glioma, is associated with a very high mortality rate. MRI is a useful method for the …
Integrative proteomic and functional analyses provide novel insights into the action of the repurposed drug candidate nitroxoline in AsPC-1 cells
We recently identified nitroxoline as a repurposed drug candidate in pancreatic cancer (PC)
showing a dose-dependent antiproliferative activity in different PC cell lines. This antibiotic is …
showing a dose-dependent antiproliferative activity in different PC cell lines. This antibiotic is …
Rationally repurposed nitroxoline inhibits preclinical models of Epstein–Barr virus-associated lymphoproliferation
Repurposing of currently used drugs for new indications benefits from known experience
with those agents. Rational repurposing can be achieved when newly uncovered molecular …
with those agents. Rational repurposing can be achieved when newly uncovered molecular …