It has been more than three decades since the first monoclonal antibody was approved by
the United States Food and Drug Administration (US FDA) in 1986, and during this time …

Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous
epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) …

Understanding the molecular basis for immune recognition of SARS-CoV-2 spike
glycoprotein antigenic sites will inform the development of improved therapeutics. We …

Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19
patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which …

The SARS-CoV-2 pandemic has led to an urgent need to understand the molecular basis for
immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the …

Antibodies that neutralize diverse strains of HIV-1 develop in∼ 20% of HIV-1-infected
individuals, and isolation and structural characterization of these antibodies are revealing …

The induction of neutralizing antibodies directed against the human immunodeficiency virus
(HIV) has received considerable attention in recent years, in part driven by renewed interest …

Broadly neutralizing antibodies (bnAbs) are potential therapeutic molecules and valuable
tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody …

IgG4 autoimmune diseases are characterized by the presence of antigen-specific
autoantibodies of the IgG4 subclass and contain well-characterized diseases such as …

A hallmark of T cell dependent (TD) humoral immune responses is the generation of long–
lived memory B cells. The generation of these cells occurs primarily in the germinal center …