Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Cancer is characterized by increased oxidative stress, an imbalance between reactive
oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of …

Background & Aims The liver is a metabolically active organ and is also 'tolerogenic',
exhibiting sophisticated mechanisms of immune regulation that prevent pathogen attacks …

The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic
organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from …

Thiram is used in large quantities in agriculture and may contaminate the environment by
improper handling or storage in chemical plants and warehouses. A review of the literature …

Metabolites have functions in the immune system independent of their conventional roles as
sources or intermediates in biosynthesis and bioenergetics. We are still in the pioneering …

Metabolite sensing is one of the most fundamental biological processes. During evolution,
multilayered mechanisms developed to sense fluctuations in a wide spectrum of …