Emerging tendencies for the nano-delivery of gambogic acid: a promising approach in oncotherapy
Despite the advancements in cancer therapies during the past few years, chemo/photo
resistance, severe toxic effects, recurrence of metastatic tumors, and non-selective targeting …
resistance, severe toxic effects, recurrence of metastatic tumors, and non-selective targeting …
Hijacking 5-Fluorouracil Chemoresistance in Triple Negative Breast Cancer via microRNAs-Loaded Chitosan Nanoparticles
Chemotherapy is still the mainstay of treatment for triple-negative breast cancer (TNBC)
patients. Yet only 20% of TNBC patients show a pathologic complete response (pCR) after …
patients. Yet only 20% of TNBC patients show a pathologic complete response (pCR) after …
Unveiling structural features, chemical reactivity, and bioactivity of a newly synthesized purine derivative through crystallography and computational approaches
We introduce the synthesis and characterization of a novel purine derivative, 2-amino-6‑
chloro-N, N-diphenyl-7H-purine-7-carboxamide. X-ray crystallography was utilized to …
chloro-N, N-diphenyl-7H-purine-7-carboxamide. X-ray crystallography was utilized to …
[HTML][HTML] Computational antidiabetic assessment of Salvia splendens L. polyphenols: SMOTE, ADME, ProTox, docking, and molecular dynamic studies
This study utilizes artificial intelligence and machine learning to enhance drug discovery,
focusing on the antidiabetic effects of Salvia splendens leaf extract among the global …
focusing on the antidiabetic effects of Salvia splendens leaf extract among the global …
PEG-PLGA core–shell nanoparticles for the controlled delivery of picoplatin–hydroxypropyl β-cyclodextrin inclusion complex in triple-negative breast cancer: In vitro …
In this study, we prepared an inclusion complex of picoplatin (Pc) with 2-hydroxy propyl β
cyclodextrin (HPCD) to improve its hydrophilicity, yielding Pc-HPCD. The Pc-HPCD complex …
cyclodextrin (HPCD) to improve its hydrophilicity, yielding Pc-HPCD. The Pc-HPCD complex …