Abstract c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however,
emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK …

Abstract c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and
survival. Emerging evidence show that JNK promoted tumour progression is involved in …

Autophagy is a self-degradative cellular process, involved in stress response such as
starvation, hypoxia, and oxidative stress. This mechanism balances macro-molecule …

Quercetin, a bioflavonoid contained in several vegetables daily consumed, has been
studied for long time for its antiinflammatory and anticancer properties. Quercetin interacts …

Bortezomib (BTZ) is the first proteasome inhibitor approved by the Food and Drug
Administration. It can bind to the amino acid residues of the 26S proteasome, thereby …

The antitumor activity of an inhibitor of 26S proteasome bortezomib (Velcade) has been
observed in various malignancies, including colon cancer, prostate cancer, breast cancer …

The inhibition of the unfolded protein response (UPR), which usually protects cancer cells
from stress, may be exploited to potentiate the cytotoxic effect of drugs inducing ER stress …

Inflammation and cancerogenesis are strongly interconnected processes, not only because
inflammation promotes DNA instability, but also because both processes are driven by …

Abstract Purpose Histone deacetylase inhibitors (HDACi) are anti-neoplastic agents that are
known to affect the growth of different cancer types, but their underlying mechanisms are still …

The JNKs are members of mitogen-activated protein kinases (MAPK) which regulate many
physiological processes including inflammatory responses, macrophages, cell proliferation …